Hello OgreMike,
Heck of a railroad you're eyeballing for your first venture! But, if you've been interested in model railroading for over 50 years, then hopefully you're old enough and wise enough to know what you're getting into with this particular layout!
Pulling out the ol' Custom-Line King Size Plan Book, and refreshing my memory for a little bit, I would say that if one disregards the yard trackage for the time being, then the main layout all of a sudden doesn't look so insurmountable. Actually, looks like a pretty cool layout that would be fun to operate. Definitely old-school, though. And I hope you wouldn't plan on ever moving again, as it would be pretty tough tough to get out of a house if you ever needed to move.
If I were going to build this layout, I'd forget the sectional track and use all flex track, and solder most of the joiners (insulated rail joiners at the reverse loops, of course). Fewer rail joints that way. But, I have plenty of experience with flex track, and you may not.
I personally like and use an NCE DCC system on my home layout and club layout. NCE is very user-friendly in my opinion, and was easy to learn on (a big help for me at the time). There's other good systems out there also. dave1905's advice on a brand (post #6) is quite worthy of consideration.
As far as wiring the layout for DCC, this is what I would do: I wouldn't worry about power districts. It's not THAT big of a layout. Looking at the layout schematic in the book, it's really just a big dog-bone with a reverse loop at each end. Get two auto-reverse loop modules, one for each reverse loop. Then, in OVERLY SIMPLISTIC terms, from you command station run two wires to the left loop auto-reverser. Run two wires to the right loop auto reverser. Then run two wires to the trackage in between the loops. That's it! Pretty easy, eh?
Well, you'll actually be running more wires than that. BUT, due to all the turnouts, they will be nothing more than jumper wires to make sure all the tracks receive power. If you really want to do power districts, that wouldn't be hard to do either. I'd probably go with 4 districts - each reverse loop, the main layout in between the loops, and the yards. Or you could have even a few more, that would be totally up to you.
As far as turnouts go, I'd probably just use Atlas powered turnouts on the mainline along with their little electrical switches. And any other places maybe a little far to reach. And just go with hand-throw turnouts in the yard and any other close-by turnouts.
Well, that's my advice, hope it's of some help. Good luck with whatever you end up doing.