Yes, and often no.
Yes if you practise and test your results often. No if you slap down what seems to look good and then attempt to wire it up permanently, hoping it'll all be okay.
There are factors that contribute to success, and all involve ridding yourself of ignorance. For example, will your choice of engines and rolling stock negotiate every inch of your track system as you configure it, forwards and backwards, towing and shoving? Some engines don't do well on curves below about 24", and even then only at a slow yard speed.
Cardinal Rule: The closer you get to stated minimums, and actual minimums that unfortunately do vary from item to item a bit, the greater the probability of indeterminate accidents (which breed unhappiness very quickly in this hobby). If, for example, your engine has a long driver base and the manufacturer states that its minimum operational radius is 22", you can expect to have three or four times the number of accidents that are indeterminate...without an apparent cause...if your curves are at or near 22". Flex or sectional track...don't matter. As you move away from the minimums, and assuming you don't make other typical errors, your indeterminate accidents will drop off to nil. Lastly, you can construct elegant and very prototypical easements into curves that you will not be able to do with sectional track. You can substitute a larger radius section at the commencement of the curve that will act much like an easement, but it won't look as good as the ones generated by flextrack.
All track must be supported evenly and joined properly. All track lengths must have all four rail ends dressed with a metal file to eliminate flange snags. This is critical on minimum curves because your flanges will, perforce, be running very close, or along, the inner face of the rail heads along the curves. Sharp road surfaces or flange faces will be among the indeterminate accident causes I was talking about.
Very specifically, each type of track has its uses and benefits. However, the benefits of flex outweigh those of sectional in the areas of cost and flexibility of curvature and lengths so that you can actually close a convoluted track loop without resorting to a three or four degree kink and hope your trains won't mind.
-Crandell