If I recall, EMD sold A-B-B-A F7s in the late '40s as 6000 horsepower road power (cabs on each end, each unit 1500 hp x 4 = 6000 hp).
Only foresee-able (ugh, spellin') with running locos back-to-back on a layout would be possible direct short on metal shank Kadees mounted on the metal frames of the locos. I haven't had much luck isolating Kadees with plastic/delrin screws, but I body-mount the couplers (build up a plastic mounting pad in the loco body), which insulates the couplers via screwing into plastic, not a metal screw/metal shank/coupler short through the frames. I had a devil of a time with an Athearn SW 1200 SP switcher shorting to a stall (I could roll it through fast and jerky with the flywheels pushing it through, but who wants a race car switcher?) when the Kadee hung down and just tapped the divergent rails on the switch/turnout. I cut off the frame metal mountin pads, glued in a stack of styrene on the body, and mounted the couplers there, no more stalling. Flat end of Athearn F unit makes a nice place for a styrene coupler mounting pad and shortens up the long coupler hangout from the back of the loco, and no problem with the coupler swing interfering on the curve. But if you keep the F7 frame mount on the loco nose, don't run the F7As nose-to nose, or same frame/coupler/frame shorting problem.
Of course, if you run more than one powered loco, you pull more juice.