Depending on the definition of "spray", it's the only way to go for me. By spray, I mean airbrush, and yes, I used lacquer thinned enamels exclusively for years. And as for cans of spray paint, the trick is just like an airbrush: many many very light coats. But canned spray paint is a LOT tougher to control and I quickly retreated and went to an airbrush exclusively.
The trick with lacquer thinned paints is to make many light coats so that the % of sovent is always kept low and evaporates quickly, whether airbrush or canned.
Bob, I never had much luck with Polly S, it was like painting with old tub caulk....others claim that a "barrier coat" will prevent plastics damage, I never tried it myself. I really liked using the Floquil lacquers, they just work sooooo well.... Didn't use too many acrylics but the Tamiya acrylic was oh-so easy to work with, and it thinned with isopropyl alcohol. (as will any water based paint; Iso "wets" better, mixers faster, dries quicker, too)
For getting around details like grabs, I learned to do these areas first, holding the model at such angles to get paint behind the grabs and such in the first few passes, again with many many light coats. Put these odd-angle coats down first, and many times the normal full frontal spray angle won't even be needed. If you do the full front spray first, you may wind up with too much paint there and none on the hidden areas.
Do the tough areas 1st is a good rule of thumb....