If the track is laid correctly with no kinks or bad joints, and the curve isn't on a grade, it will work. It won't look too good due to the amount of overhang and you'll have to check your clearances because those big front porches will really stick out. However, if you really want to run six axle power like an SD-40, it will work.
Yes, it can as long as you keep the track in good condition..