Yes, 22" radius is not a good idea. There is a thing called grade equivalent where the curvature of a helix causes a train to experience a grade significantly higher than the simple rise/run grade. One guy explained it wells as follows:
"The difference between the 4% and 2.5% for a 24" radius is caused by the grade equivalent. Grade equivalent, which was discussed earlier in this tread, is the drag (expressed as a grade) that a train sees from going through a curve. There is actually a complicated formula to figure this out, however there is also an easy rule of thumb for HO. Basically 32/radius of the curve= grade equivalent. So a train going through a LEVEL 24" radius curve will experience a drag equivalent to a 32/24 = 1.33 degree grade. So if a 24" radius helix produces an actual 2.65% grade (~2.5%) then the train will experience an almost 4% grade. The minimum radius I would use for a helix is 30 inches if you have the room."
There is a lengthy discussion at MRH forums that also might be good to read.
http://model-railroad-hobbyist.com/node/28784?page=4
So keeping in mind if you have a 30" radius track helix and want a 2% actual grade, your going to get 3.8" rise for every 360 degree turn. Remember, circumference = 2 x Pi x Radius and Grade = Rise over Run. So even with a 30" radius helix, the train is going to experience a grade, due to drag of the curve will be 2.8% and that's assuming a separation of 3.8 inches between turns allows sufficient clearance when taking into account subroadbed thickness and track etc. I'd allow for a full inch for that, so with a 30" radius curve helix at 2.0% actual grade with 1 inch thickness and 1/16" track - you'll have 2.6 inches over the head of the rails. Is 2.6 inches enough to clear your tallest rolling stock? What about finger space if you need to re-rail cars? Just some factors to figure in on.