On long driver bases on steamers, the problem is often the track. The drivers may stay railed going over warped track, but whatever is in front of them or behind them may get levered up and lifted off...literally.
Does this happen randomly, or is there a measured and discernible concentration in one or three spots?
Note that 22" is really on the low margins of tolerance for a scale 79" diameter driver, with four of them arranged in a row. Every steamer I have purchased and introduced to my layout has caused me some humility. Honestly, without a word of a lie, each time I have purchased a steamer, I have had to shim or tweak some track. My latest steamer was a BLI Hybrid 2-10-2. I had run all sorts of articulated engines, a BLI Duplex, a Pennsy J1 2-10-4, etc. with no problems for two years. Got the new TTT-6 and within two weeks I knew I had to rip up 3' of track, all nicely ballasted and weathered, and have at 'er....AGAIN!!! Now, seven months later, I wonder what all the fuss was about.
Other than that, you may have some flashing or warped parts. Maybe some plastic grit and bits that occasionally snag during a sideways swing into a turn. I would remove the truck, inspect the under-cab bolster or mounting pintle carefully in good light and with some magnification, and do the same to the truck. Clean and lube with Dextron III ATF. Check that the wheels are aligned back to front, flanges aligned, when you slide both axles tight to the left and tight to the right in their frames. You may spot a misalignment. If the flanges don't line up.......
When the truck sits by itself on a flat, clean surface, are all four flanges making contact with the surface? Is the frame obviously bent?
That's about all I would know to check. It may be that all you need is to apply some stick-on weight. If you can't do that any practical way, wrap some lead wire around both axles and paint it black.
-Crandell