My first pass was to simply put your drawing into XTRK. I think you've got a great foundation for a layout.
Obvious design problems I see:
>> The circles are 30" radius, representing operator's reach. There is quite a bit of inaccessible layout in the corners. Not a problem if your trackwork is
amazing, but lets face it, no one's is. I'd either limit track in that area to main line with no switches, or figure out how to get access to it easily. A step stool will only add so much reach, and even then you'll be climbing on the layout.
>> The crossover at the back of the layout needs to be on the other side of the yard lead so that the yard tracks can be another 9" longer.
>> I used 2" track-to-track centers spacing per this 'standards' document.
http://urbaneagle.com/data/RRstddims.html It actually suggests 3" centers on curves which I did not do, but probably should be done.
>> The same standards page lists railhead-to-railhead clearance at 4" vertically. Assuming all your track is at the same elevation except the part that does the bridge, you don't have near enough room to get up and over the other piece of track with reasonable grades ( ascents / descents ). Typical acceptible grade on a small layout is 3% (raise 3 inches per 100 inches of travel). One side of this bridge is 9.2%, the other is 3.5%. I have ideas for adjusting this.
>> Most importantly of all, however, is that all your industry leads are on the far side of the layout. If you're operating turnouts manually you'll get tired of that real quick. If you're automating it gets expensive and complicated real quick. And furthermore, this is the interesting stuff to play with. It should be up close where you can mess with it. Also, if it fails, it's a pain to get to.
>> You don't have a way to turn an engine around. Reversing wye, reversing loop, turntable ... they're more trouble to wire, but often times are very handy to have on a layout.
Depending on how much you're willing to change, I think you could have a really fun layout in your space. I can provide you with the file I created for this layout, but you're on your own to find help learning to use XTRKCad.
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Lovely Wendie99